<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">肥胖与21种主要疾病有关,这下你是真的要减肥了!</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-03-22</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">博文</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创:医学界内分泌频道</em></h2></div><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">去年6月,《柳叶刀》子刊揭秘了中国肥胖大流行的原因后,引起了大家的强烈兴趣。这不,《柳叶刀》今年又拿肥胖“开刀”了!</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">The Lancet Diabetes &amp; Endocrinology最近的这项研究直接将肥胖作为常见疾病的共同危险因素进行检查,发现<strong>肥胖与21种主要疾病有关,且这些疾病相互关联。</strong>与健康体重的参与者相比,<strong>肥胖参与者的复杂多发病风险高出 12.4 倍!</strong></span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><img class="rich_pages wxw-img js_insertlocalimg" src="https://studioyszimg.yxj.org.cn/AC14B024017FAC160107AA305645DAC7.jpg" style="margin: 0px; padding: 0px; vertical-align: bottom; overflow-wrap: break-word ;"/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; overflow-wrap: break-word !important; box-sizing: border-box !important;"></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 14px; color: rgb(136, 136, 136);">图1 截图来源:The Lancet Diabetes &amp; Endocrinology</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><h1 style="margin: 0px; padding: 0px; font-weight: 400; font-size: 16px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(215, 0, 15); overflow-wrap: break-word !important; box-sizing: border-box !important;">“一胖毁所有”可不是闹着玩儿的</span></strong></h1></section></section></section></section></section></section></section></section></section></section></section></section></section><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section></section></section></section></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">该观察性研究使用了来自两项芬兰队列研究(健康与社会支持研究和芬兰公共部门研究)的汇总前瞻性数据,其中包括114657名年龄在16~78岁的成年人(平均随访时间12.1年)和来自英国生物银行的499357名成年人(研究开始时年龄为38~73岁;平均随访时间11.8年)。并根据参与者的身体质量指数(BMI)将他们分成以下4类:</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">&nbsp;</span></section><ul class=" list-paddingleft-2"><li><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">肥胖:</span></strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">BMI≥ 30.0kg/m<sup>2</sup>。肥胖进一步又分为1级肥胖(BMI 30.0kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>~ 34.9 kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>)、2级肥胖(35.0&nbsp;kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>&nbsp;~&nbsp;39.9 kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>)和3级肥胖(≥40kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>);</span></section></li></ul><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><ul class=" list-paddingleft-2"><li><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">超重:</span></strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">BMI在25.0&nbsp;kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>~&nbsp;29.9 kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>;</span></section></li></ul><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><ul class=" list-paddingleft-2"><li><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">体重正常:</span></strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">BMI在18.5kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>~ 24.9kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>;</span></section></li></ul><p style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;"></span></p><p style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></span></p><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;"></span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"></section><ul class=" list-paddingleft-2"><li><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important; text-align: justify;"><strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">体重不足:</span></strong><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 16px; overflow-wrap: break-word !important; box-sizing: border-box !important;">BMI&lt;18.5kg/<span style="font-size: 16px; text-align: justify;">m</span><sup style="text-align: justify; white-space: normal;">2</sup>。</span></section></li></ul><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">该项研究采用分析肥胖的风险比(HR≥1.50)和计算人群归因分数(PAF)以关联研究者的健康数据。并在调整了教育背景、吸烟、饮酒和体力活动等混杂因素后,研究者分析发现:</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">▌<strong>肥胖与21种疾病密切相关</strong>(HR≥1.50,p&lt;0.0006),最常发生的相关疾病包括<strong>内分泌疾病</strong>[所有成人糖尿病(75.4%)]、<strong>心血管疾病</strong>[高血压(71.8%)、心绞痛、心肌梗死、心力衰竭、心律失常(34.4%)、脑梗死、深静脉血栓形成、肺栓塞)],<strong>消化系统疾病</strong>(胰腺炎、肝病),<strong>感染性疾病</strong>[细菌感染(31.3%)],<strong>肌肉骨骼疾病</strong>[痛风、骨关节炎(42.1%)、背痛],<strong>呼吸系统疾病</strong>[哮喘(22.1%)],<strong>恶性疾病</strong>(肾癌),<strong>皮肤病</strong>(皮肤感染和湿疹),<strong>血液系统疾病</strong>(贫血),<strong>泌尿生殖系统疾病</strong>(肾功能衰竭)和<strong>神经系统疾病[睡眠障碍</strong>(42.6%)]。</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 14px; color: rgb(136, 136, 136);">表1 肥胖参与者中肥胖相关疾病的比例(按人数)</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><img class="rich_pages wxw-img js_insertlocalimg" src="https://studioyszimg.yxj.org.cn/AC14B024017FAC16026EA5D737E778C0.jpg" style="margin: 0px; padding: 0px; vertical-align: bottom; overflow-wrap: break-word ;"/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">▌研究中还提到,由于这21种疾病相互关联,因此<strong>每种肥胖相关疾病都可以预测或被一种或多种其他肥胖相关疾病预测。</strong>其次,这种相互关联也加速了肥胖相关多发病的发展。而肥胖的程度与复杂多发病的发病风险之间呈剂量反应关系,这种关联在3级肥胖的参与者中表现最为突出。这也就意味着,<strong>肥胖的分级越高,复杂多发病的相对风险就越大。</strong></span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">就拿死亡风险来说,芬兰队列中的结果表明,肥胖人群的总体全因死亡风险增加32%(HR=1.32),其中患3级肥胖人群的死亡风险增加90%(HR=1.90)。</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">▌<strong>与健康体重的人相比,肥胖人群至少患一种与肥胖相关疾病的风险是前者的2.83倍</strong>(HR=2.83),<strong>患两种相关疾病的风险是前者的5.17倍</strong>(HR=5.17),<strong>发生复杂多发病的风险是前者约12.39倍</strong>(HR=12.39)。</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">▌在发病年龄方面,<strong>相比健康体重的人群,肥胖的参与者在30岁左右,</strong>其普通的多发病就会开始增加;在约45岁时复杂多发病也开始显现。随着年龄的增长,这种影响也会持续存在。</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">例如在芬兰的队列中,75岁健康体重人群的复杂多发病的比例,肥胖人群在55岁就已经达到了。</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><img class="rich_pages wxw-img js_insertlocalimg" src="https://studioyszimg.yxj.org.cn/AC14B024017FAC16040310582BADAC73.jpg" style="margin: 0px; padding: 0px; vertical-align: bottom; overflow-wrap: break-word ;"/></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; white-space: normal; text-align: center; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 14px; color: rgb(136, 136, 136);">图2 肥胖相关的简单多病和复杂多病的累积发病率</span></section><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br/></section><p style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);">研究者指出,肥胖与这一系列的多重疾病之间相互关联,那也就表明,<strong>干预肥胖是预防复杂多发病的一个重要且可行的方法。</strong>拥有健康的生活方式,减少导致肥胖的风险因素,是减少人群患复杂多发病的简单方法;对于肥胖症的治疗,可通过生活方式干预、药物治疗和减肥手术等治疗,也可以有效防止患者患复杂多发病。</span></p><p style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important; font-size: 16px; font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; color: rgb(0, 0, 0);"><br/></span></p><section style="margin: 0px; padding: 0px; max-width: 100%; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: justify; white-space: normal; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px; padding: 0px; max-width: 100%; line-height: 1.75em; overflow-wrap: break-word !important; box-sizing: border-box !important;"></section></section></section></section></section></section></section></section></section><div class="footer"><div class="item"><p class="ysz-ueditor-references-label" >参考文献 <span>共1篇<i></i></span></p><div class="ysz-ueditor-references-content textLine2" lang="en"><p>[1] <span class="appskip" data-appskip="yxjysz" data-appskipobj="{&quot;type&quot;:18,&quot;id&quot;:0,&quot;title&quot;:&quot;&quot;,&quot;url&quot;:&quot;https://doi.org/10.1016/s2213-8587(22)00033-x.ysz_link&quot;}">Kivimäki, M., Strandberg, T., Pentti, J., Nyberg, S. T., Frank, P., Jokela, M., ... &amp; Ferrie, J. E. (2022). Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study. The Lancet Diabetes &amp; Endocrinology.</span></p></div></div>

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