<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">每天午睡超过1小时,痴呆风险升高40%</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-04-29</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创:医学界神经病学频道</em></h2></div><p class="brief">睡得越久,痴呆越快。</p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;">没想到白天打个盹儿,还和阿尔茨海默病(Alzheimer’s dementia,AD)有瓜葛……最近,在Alzheimer&#39;s &amp; dementia : the journal of the Alzheimer&#39;s Association杂志上发表了一篇关于AD和白天打盹儿的文章,十分有意思。</span></p><p style="text-align: justify;"><br/></p><p style="text-align: center;"><img src="https://studioyszimg.yxj.org.cn/2022042815045600044.png" title="" alt=""/></p><p style="text-align: center;"><span style="line-height: 28px; color: rgb(136, 136, 136); font-size: 14px;">(发布在Alzheimers Dement.上的原文)</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">该项研究由美国加州大学精神病学和行为科学系冷月教授团队完成,探索了AD和白天打盹儿两者之前到底有着怎样联系。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">累了,困了,打个盹儿,说的就是你吗?</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">老年人白天打盹过多的现象非常普遍,特别是AD患者的睡眠觉醒障碍和白天小睡的现象更为明显;另一方面来讲,白天打盹和小睡过度,这可能是长时间和频繁午睡的原因,也与认知能力更快下降或AD病理积聚有关。</span></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;"><br/></span></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;">虽然一些研究表明,午睡(尤其是在年轻人群中)对急性认知能力、情绪和警觉性有好处;但其他研究强调午睡也与长期的不良后果有关,其中也包括了认知能力差。</span><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">一时打盹儿一时爽,但是打盹的时间和频次竟然和AD有关系?</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">在这项新研究中,研究人员分析了以往的研究,发现之前大部分关于AD的研究都只评估了一次参与者的午睡情况,使用的是主观的午睡评估,这可能不可靠,而且大多数研究都是基于调查问卷。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">特别是老年人的认知状态还需要通过对午睡进行纵向评估,来了解白天小睡和AD之间有着怎样错综复杂的联系?</span></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;"><br/></span></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;">因此,他们对午睡进行纵向、客观的评估,尝试去确定午睡和AD之间的联系。</span><br/></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">在该项研究中,他们主要测试了两个假设:</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">1.&nbsp;随着年龄的增长,受试者午睡的时间更长或更频繁,这种纵向变化随着受试者从没有认知障碍(&nbsp;no cognitive impairment&nbsp;,NCI)到轻度认知障碍(mild cognitive impairment ,MCI)的进展而加剧,并在被诊断为AD后进一步加快;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">2.&nbsp;白天小睡过多的受试者患AD的风险增加。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">因此,研究人员分析了一项正在进行的Rush Memory and Aging Project(MAP)的研究数据。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">MAP项目始于1997年,是一项前瞻性队列研究,纳入1401位受试者,平均年龄为81.4岁,其中女性1065人,占比76.5%。研究者们对受试者白天午睡的纵向变化进行检查,1065名受试者至少进行了两次活动测量评估。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">其中,在基线时812例是NCI,209例为MCI,44例被诊断为AD。所有受试者每年连续在手腕处佩戴一种活动记录的设备14天,该研究随访时间长达14年。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">老年人白天悠闲打盹,痴呆在路上......</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">在随访的14年中,研究人员发现受试者午睡时间会随着认知障碍的严重程度增加:</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">对于没有出现认知障碍的受试者,在NCI期间,午睡时间随着时间的推移而增加,平均每年睡眠时长增加了11分钟左右;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">但是,在MCI诊断后,午睡时间相较于NCI时期增加了一倍,平均每年睡眠时长增加了13分钟,即较没有出现认知障碍的受试者增加了24分钟左右;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">被诊断为AD的受试者的午睡时间相较于NCI期间更是几乎增加了6倍,相较于MCI时期平均每年增加了43分钟,即较没有出现认知障碍的受试者增加了68分钟。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: center;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><img src="https://studioyszimg.yxj.org.cn/2022042815062900045.png" title="" alt="" style="text-align: center; white-space: normal;"/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span style="color: rgb(0, 0, 0); font-size: 16px;">此外,随着年龄的增长,受试者午睡的频率也会增加,</span><span style="color: rgb(0, 0, 0); font-size: 16px;">MCI诊断后发生率会翻倍,在被诊断为AD后,发生率又增加了近一倍。</span><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">正如研究数据结果中呈现(图2),每天至少午睡一次或每天午睡时间超过一小时以上的受试者患AD的风险比每天午睡时间小于1小时的受试者高出40%。随着年龄和疾病发展,尤其是在出现AD的临床表现后,午睡时间和频率的增加会加速。</span></p><p style="text-align: center;"><br/></p><p style="text-align: center;"><span style="line-height: 28px; color: rgb(136, 136, 136); font-size: 14px;"><img src="https://studioyszimg.yxj.org.cn/2022042815073100046.png" title="" alt=""/></span></p><p style="text-align: center;"><span style="line-height: 28px; color: rgb(136, 136, 136); font-size: 14px;">图2(白天午睡与AD之间的关系。)</span></p><p style="text-align: center;"><span style="line-height: 28px; color: rgb(136, 136, 136); font-size: 14px;">A、B图显示预测的平均小睡持续时间(A)和小睡频率(B);C、D图显示了两个代表性个体的午睡持续时间(C)或午睡频率(D)</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">打盹越多,痴呆越快</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">研究过程中,研究人员发现,午睡时间、午睡频率与年龄呈正相关,并发现午睡与AD之间存在双向的纵向关联:白天小睡时间越长、越频繁,患老年痴呆症的风险就越高。所以,更长时间和更频繁的午睡也是正常老年人患阿尔茨海默病的风险因素。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">同样研究者们,还发现了一个有趣的现象:白天打盹次数越多或时间越长,其认知能力越差,反之,认知能力越差,其打盹儿次数则越多,如此往复便形成了一种“恶性循环”。在这种恶性循环中,AD与午睡时间和频率的大幅增加有关,而长时间和频繁的午睡则与患病风险的增加和认知能力的恶化有关。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">对于打盹儿这件事儿,看看专家怎么说?</span></p><p style="text-align: justify;"><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">阿尔茨海默病协会科学总监Percy Griffin教授评论道:“这项研究特别强大和不同的地方在于它的直接检测、大队列规模和纵向跟踪。”他指出,该项研究主要的限制是年龄的限制,还需做进一步的研究,对于那些已经确诊患有AD的人来说,午睡频率和持续时间的变化可能预示着疾病进展的加速,可以采用药物和非药物方法来帮助减缓这些变化的影响。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">正如Percy Griffin教授所言,研究人员也表示,这项研究仍存在一些的局限性,包括被研究的受试者年龄较大,中年或年轻群体的打盹行为是否与晚年的AD的发生或认知功能下降有关联,还需在未来做进一步研究。</span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"></span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 1.75em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);">为进一步对研究进行解读,“医学界神经病学频道”特邀国内AD领域专家首都医科大学宣武医院韩璎教授点评:</span><br/></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: justify; line-height: 1.75em;"><br/></section><section style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 677px; line-height: 1.75em;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 55px;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; border-radius: 100%; width: 55px; height: 55px; overflow: hidden;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1160180A699F05EDF3360950AAE.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; font-size: 15px; letter-spacing: 0.54px; text-align: center; white-space: normal; widows: 1; background-color: rgb(250, 250, 250); box-sizing: border-box ; overflow-wrap: break-word ; visibility: visible ; width: 187px ;"/></section></section><p style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; white-space: normal; color: rgb(102, 102, 102); letter-spacing: 1.5px; font-size: 16px; width: 677px; line-height: 1.75em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br/></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-start; align-items: center;"><span style="margin: 10px auto; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; letter-spacing: 1.5px; width: 677px; line-height: 1.75em; color: rgb(89, 87, 87); font-weight: bold; font-size: 15px;">&nbsp;&nbsp;<strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; white-space: normal;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px;">韩璎教授 首都医科大学宣武医院</span></strong></span></section><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><br/></p></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; width: 0px; height: 15px; overflow: hidden; border-right: 15px solid transparent; border-bottom: 15px solid rgb(242, 242, 242); line-height: 1.75em;"><br/></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; background: rgb(242, 242, 242); border-bottom-left-radius: 15px; border-bottom-right-radius: 15px; border-top-right-radius: 15px;"><section style="margin: 0px; padding: 1em; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 14px; letter-spacing: 1.5px; line-height: 1.75em;"><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; white-space: normal; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">我们中国认知下降纵向研究(</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">Sino</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">&nbsp;</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">Lo</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">ngitudinal Study on Cognitive Decline, SILCODE</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">)</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">队列采纳的《艾普沃斯嗜睡量表》</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">(</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">Epworth Sleepiness Scale</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">,</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">ESS</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">)</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">,就是用来评价老年人近几个月来在某些日常行为中打瞌睡的可能性。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">得分</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">越高,表明日间打瞌睡的可能性越大。</span><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(89, 87, 87); font-size: 16px;">那么日间瞌睡可能性大意味着什么呢?</span><br/></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);"><br/></span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);">2022年3月17日,Alzheimer&#39;s &amp; dementia: the journal of the Alzheimer&#39;s Association(《阿尔茨海默病协会杂志:阿尔茨海默病与痴呆》)发表的“Daytime napping and Alzheimer’s dementia: A potential bidirectional relationship”研究就很好地回答了这个问题。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);"><br/></span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);">日间瞌睡增多和认知功能下降之间具有双向关系。老年人日间瞌睡增多现象很常见,却很少有人把它与阿尔茨海默病(Alzheimer’s disease, AD)联系起来。该项研究从科学的角度证实了两者之间的确存在着双向的关系。值得我们重视。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);"><br/></span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: justify; line-height: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 16px; color: rgb(89, 87, 87);">AD是痴呆最常见的类型,其致病机理不明,临床前期可以长达15-20年。如果能够在临床前期发现并开始干预,将会降低未来一半的AD痴呆患病人数。临床前期没有明显的临床症状,很难发现。但是,老年人的日间瞌睡增加,会提高认知下降的风险,这将对于我们未来在临床前期识别AD患病风险是一个敏感而实用的指标。</span></p></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em;"><br/></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; white-space: normal;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; letter-spacing: 0.54px; line-height: 27.2px; widows: 1;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; letter-spacing: 0.54px;"><section style="margin: 20px 0px 0px; padding: 5px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; background-color: rgb(250, 250, 250); border-color: rgb(204, 204, 204); border-style: solid; border-width: 1px; box-shadow: rgb(165, 165, 165) 5px 5px 2px; line-height: 24px;"><section style="margin: -18px 8px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 0px; padding: 4px 20px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; border-radius: 0.1em 1.5em; border-width: 1px; border-style: solid; border-color: rgb(237, 15, 15); text-align: justify; color: rgb(254, 254, 254); display: inline-block; box-shadow: rgb(165, 165, 165) 4px 4px 2px; background-color: rgb(237, 15, 15);"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">专家简介</strong></section></section><section style="margin: 0px; padding: 15px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center; line-height: normal; min-height: 1em;"><br/></section><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: center; box-sizing: border-box !important; overflow-wrap: break-word !important;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1160180A699F05EDF3360950AAE.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; visibility: visible ; width: 187px ;"/></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em; text-align: center;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(136, 136, 136);">韩璎教授</span></strong><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(136, 136, 136);"></span></section><p style="margin-bottom: 0em; padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; text-align: center; box-sizing: border-box !important; overflow-wrap: break-word !important;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1160180A699F2D4AF4C5514A172.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; width: 243px ; visibility: visible ;"/></p><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.75em;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(136, 136, 136);">首都医科大学宣武医院神经内科主任医师、博士生导师,中华医学会放射学分会磁共振专委会委员,北京认知神经科学学会理事长,国家老年疾病临床医学中心-中国AD临床前期联盟主席,国内外多家学术期刊编委和审稿专家。国自然评审专家。</span></section></section></section></section></section></section></section><p style="text-align: justify;"><br/></p><p><br/></p><!--auditorInfo-->

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