<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">做到这4点，狼疮患病风险可降低50%！</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-05-13</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">卷卷</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创：医学界风湿免疫频道</em></h2></div><p class="brief">好好吃饭，真的是有用的！</p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">作为常见慢性系统性风湿免疫病的代表，系统性红斑狼疮（SLE）是一种青年女性高发、慢性、系统性自身免疫性疾病，以患者血液中存在大量自身抗体和多器官受累为突出临床特征，以疾病缓解与复发交替为病程特点，临床表现复杂、异质性强，易造成肾脏、血液及神经系统等重要脏器损害，是一种严重威胁我国国民健康的重大慢性疾病。我国SLE的患病率约为30/10万～70/10万，居世界第二位。据此估算，目前我国约有100万SLE患者，SLE已成为我国常见的自身免疫性疾病之一^［1］。</span></p><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section><section><section><section><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">遗传+环境因素是SLE发病的原罪</span></p></section></section></section></section></section></section></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">遗传因素和环境暴露复杂的相互作用被认为与SLE发病有关。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section><section><section><section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">一级亲属中患有SLE的受试者，大约5%-12%将会发展为SLE；在具有先天性补体C4缺乏的人中，高达90%的受试者会发展为SLE。</span></section><section><br/></section><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">环境暴露，例如紫外线、药物、传染源、二氧化硅、香烟烟雾、酒精、激素因素和肥胖已被认为与SLE的发展有关，尽管这些关联的强度各不相同。环境暴露导致SLE风险增高的潜在生物学机制包括全身炎症增加、氧化应激、炎性细胞因子的上调和表观遗传修饰。</span></p></section></section></section><section><section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section><p><br/></p></section></section></section></section></section></section></section><section><section><section><section><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">健康的生活，不只对三高有好处</span></p></section></section></section></section></section></section></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">都知道遗传因素控制不了，环境因素或许还可以努力改变一下。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">既往研究称，拥有较高的健康生活方式指数评分（HLIS）可降低患各种疾病的风险，包括心血管疾病、中风、心源性猝死、糖尿病和癌症，以及延长寿命。不仅如此，研究表明，采用更健康的生活方式还可以降低自身免疫性疾病（如SLE）风险。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">不服？研究数据来说话！</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">既往的护士健康研究（NHS）和护士健康研究Ⅱ（NHS&nbsp;Ⅱ）研究中发现^[2-4]：</span></section><section><section><section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section><p><br/></p></section></section></section></section></section></section><section><section><section><section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">目前吸烟者患抗dsDNA阳性SLE的风险比从不吸烟者高86%（HR 1.86，95%CI 1.14-13.04）；</span></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">与BMI正常女性相比，肥胖女性患SLE的风险高85%（HR 1.85, 95%CI 1.17-2.91）；</span></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">适度饮酒（5g/天）可将SLE发病风险降低39%（HR 0.61，95%CI 0.41-0.89）。&nbsp;</span></section></section></section></section></section><section><section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section><p><br/></p></section></section></section></section></section></section></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">问题来了，既然单个健康生活方式都对降低SLE风险有作用，那么同时拥有多个健康生活方式，是不是更加多多益善？1+1&gt;2真的可能吗？</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section><section><section><section><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">拥有≥4项健康生活方式，SLE的发病风险降低一半？</span></p></section></section></section></section></section></section></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">近期的一项研究^[5]替我们回答了这个问题，坚持≥4项健康生活方式，SLE的发病风险可降低近50%。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: center;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1620180B7F2E4720AD20DF252A2.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; width: 677px ; visibility: visible ;"/></section><section style="text-align: center;"><span style="line-height: 28px; color: rgb(136, 136, 136); font-size: 14px;">文献截图</span><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);"><br/></span></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">该研究共纳入了来自NHS和NHSⅡ队列的185962名女性，在4649477人·年的随访中发生了203例SLE事件（96例抗dsDNA抗体阳性，107例抗dsDNA抗体阴性）。在基线和每2年时计算一次HLIS（0-5分），HLIS包括以下5个方面：</span></section><section><section><section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section><p><br/></p></section></section></section></section></section></section><ul class="custom_macula list-paddingleft-1" style="list-style-type: macula;"><li class="list-macula list-macula-paddingleft"><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">从不吸烟或过去吸烟（戒烟超过4年）；</span></p></li><li class="list-macula list-macula-paddingleft"><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">适量饮酒（≥5g/天）；</span></p></li><li class="list-macula list-macula-paddingleft"><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">健康体重（BMI＜25kg/m²）；</span></p></li><li class="list-macula list-macula-paddingleft"><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">规律锻炼[代谢当量任务（MET）≥19-小时/周，相当于每天快走30分钟]；</span></p></li><li class="list-macula list-macula-paddingleft"><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">健康饮食[替代健康饮食指数（AHEI）中的前40%]。</span></p></section></section></section></li></ul><section><section><section></section></section></section><section><section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section></section></section></section></section><section><section><section><section><p><br/></p></section></section></section></section></section></section></section><section><section><section><section><section><section><section><section></section></section></section></section></section><section><section><section><section><section></section></section></section></section></section><section><section><p style="text-align: justify;"><strong><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">结果发现：</span></strong></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p></section></section></section></section></section><section><section><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">在多变量模型中，较高的HLIS与较低的SLE总体风险（HR：0.81，95% CI：0.71-0.94）和抗dsDNA阳性SLE风险（HR：0.78，95% CI：0.63-0.95）相关（表1）；</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">与具有≤1种健康行为的女性相比，具有≥4种健康行为的女性总SLE发病风险（HR=0.42，95%CI：0.25-0.70）和抗ds-DNA抗体阳性的SLE发病风险（HR=0.35，95%CI：0.17-0.75）最低；</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">至少坚持4种健康的生活方式，在SLE发病风险中的人群归因风险百分比（PAR%）为47.7%（95%CI：23.1%-66.6%）。</span></p><section><br/></section><section style="text-align: justify;"><strong><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">此外，HLIS每增加1分</span></strong></section><section><br/></section><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">SLE总体风险可降低19%（HR 0.81，95%CI 0.71-0.94）；</span></p><p><br/></p><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">抗ds-DNA抗体阳性SLE的风险可降低22%（HR 0.78，95%CI 0.63-0.95）（表 1）；</span></section><p><br/></p><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">抗ds-DNA抗体阴性SLE的风险会降低15%（HR 0.85，95%CI 0.70-1.03），但无统计学意义。</span></section><p><br/></p><p style="text-align: center;"><span style="line-height: 28px; font-size: 14px; color: rgb(136, 136, 136);">表1：5种健康生活方式与SLE发作风险的关系<br/></span></p><p style="text-align: center;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1620180B7F2E55FFA4E01DD6422.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; width: 677px ; visibility: visible ;"/></p></section></section></section><section><section><section></section></section></section></section></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">这篇研究的结果用大白话来说，就是不吸烟、适度饮酒、体重正常、规律锻炼以及健康饮食对降低得SLE的风险有好处，并且满足4个或以上时，几乎可以降低得SLE的一半风险！仔细想想，相比较患SLE后与药为伍的日子，上述健康行为其实不难做到！具体要如何做，小编就来给大家详细说说。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;&nbsp; &nbsp; &nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</span></section><section><section><section><section><section><section><section><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">为了自己的健康，冲！</span></p></section></section></section></section></section></section></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">以上健康行为中，戒烟、适量饮酒、保持健康体重以及锻炼这些小编就不多加赘述了，主要来说一下SLE患者饮食要注意的方面。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">我们可以注意到上述研究中提到了AHEI，AHEI是根据美国人的饮食制订的指南，旨在降低慢性疾病的风险，2012年Nutrion发布的AHEI-2010是该指数的更新版本（现已更新至2015-2020版本）^[6]。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">AHEI-2010是以食物金字塔及膳食指南为依据设计，包括11种成分：水果、蔬菜、全谷物、坚果和豆类、长链（n-3）脂肪酸、多不饱和脂肪酸、含糖饮料和果汁、红肉和加工肉类、反式脂肪酸、钠以及含酒精饮品。每一种得分按照摄入频率为0-10分不等，总分为0-110分，前6种摄入频率越高，得分越高，后几种则相反^[7]。衡量标准为AHEI-2010综合评分&gt;80分即为健康饮食模式。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">看来，多吃果蔬、全谷物、坚果和豆类等对身体真的是有好处的！同时，SLE患者一定要控制对糖、红肉、反式脂肪酸、盐等的摄入，这些成分真的是肥胖的罪魁祸首！</span></section><section><br/></section><section style="text-align: center;"><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1620180B7F2E6ADD8FF00028468.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; width: 336px ; visibility: visible ;"/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">此外，少吃盐真的不是说说而已，盐对自免疫系统疾病患者极不友好，一项研究^[8]指出，盐能同时影响先天免疫系统和适应性免疫系统，导致炎症更容易发生；临床研究证实高盐分食物会减少肠道的乳杆菌，搞乱肠道的菌群平衡；盐增加免疫Th17细胞的数量导致炎症加剧……总之，SLE患者需要减少用盐和食用添加盐的食物。</span></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;&nbsp;&nbsp;</span></section><section><section><section><section><section style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">点评：</span></section><section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">SLE是一种复杂、机制不明的多系统受累的自身免疫性疾病。该项研究证实生活习惯可以降低健康人群中SLE的发病。目前大量研究证实健康生活因素不仅可以降低病情复发，而且能预防重要脏器受累。</span></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">吸烟除了增加心脑血管疾病的发生，同时增加呼吸道感染，降低药物的疗效，促进SLE复发以及健康人群患病风险。适量饮酒可以提高高密度脂蛋白（HDL），抵抗血管硬化，而过度饮酒影响药物疗效及相关副作用。因此，控制酒精摄入可预防疾病发生。规律锻炼可以增加机体抵抗力、调节情绪、减轻压力。另外，对于SLE患者，避免日光照射也是SLE患者的日常注意事项之一。除此之外，均衡饮食在调控免疫系统，控制炎症方面至关重要。</span></section><section><br/></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">为了降低健康人群发生自身免疫性疾病的风险，健康的生活方式尤为重要。因此，正确的生活习惯及饮食在各类慢性疾病中值得倡导。</span></section></section></section></section></section></section><section style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">&nbsp;<br/></span></section><section><section><section><section><section><section><section><section><section><section style="text-align: justify;"><strong><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">专家简介</span></strong></section></section><section><section><br/></section><section style="text-align: center;"><strong><img class="rich_pages wxw-img" src="https://studioyszimg.yxj.org.cn/AC14B1620180B7F2E84655175919B32A.jpg" alt="图片" style="margin: 0px; padding: 0px; outline: 0px; vertical-align: bottom; box-sizing: border-box ; overflow-wrap: break-word ; width: 105px ; visibility: visible ;"/></strong></section><section style="text-align: center;"><strong><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">罗雄燕&nbsp;副主任医师</span></strong><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);"><br/></span></section><section><br/></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">四川大学华西医院风湿免疫科医学博士，副主任医师&nbsp;</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">海峡两岸医药卫生交流协会风湿免疫病学专业委员会委员</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">海峡两岸医药卫生交流协会风湿免疫病学专业委员会眼免疫学组委员</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">四川省免疫学会第二届风湿免疫专业委员会委员</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">《中华临床免疫和变态反应杂志》青年编委</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">2017-2018年在美国访问学习</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">承担国家自然科学基金、四川省科技厅项目、中华医学会资助项目和四川卫生厅等项目，撰写并发表数篇SCI论文，约20篇核心中文期刊文章&nbsp;</span></section><section style="text-align: justify;"><span style="line-height: 28px; font-size: 15px; color: rgb(136, 136, 136);">参与论著《关节炎诊断与治疗》、《今日风湿家园》及《凯利风湿病学》等编写</span></section></section></section></section></section></section></section></section></section></section><!--auditorInfo--><div class="footer"><div class="item"><p class="ysz-ueditor-references-label" >参考文献 <span>共8篇<i></i></span></p><div class="ysz-ueditor-references-content textLine2" lang="en"><section><section><span style="color: rgb(136, 136, 136); font-size: 16px; text-align: justify;">[1]ZHU TY,Tam LS,Lee VW,et al．The impact of flare on disease costs of patients with systemic lupus erythematosus[J].Arthritis Rheum,2009，61：1159-1167． <br/></span></section></section><section><section><section><section><section><section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[2]&nbsp;Barbhaiya M, Tedeschi SK, Lu B, Malspeis S, Kreps D, Sparks JA, et al. Cigarette smoking and the risk of systemic lupus erythematosus, overall and by anti-double stranded DNA antibody subtype, in the Nurses&#39; Health Study cohorts. Ann Rheum Dis. 2018;77(2):196-202.</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[3]&nbsp;Tedeschi SK, Barbhaiya M, Malspeis S, Lu B, Sparks JA, Karlson EW, et al. Obesity and the risk of systemic lupus erythematosus among women in the Nurses&#39; Health Studies. Semin Arthritis Rheum. 2017;47(3):376-83.</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[4]&nbsp;Barbhaiya M, Lu B, Sparks JA, Malspeis S, Chang SC, Karlson EW, et al. Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses&#39; Health Study &nbsp;Cohorts. Arthritis Care Res (Hoboken). 2017;69(3):384-92.</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[5]May Y Choi, MPH, FRCPCA ,et al.Combination of Healthy Lifestyle Behaviors Reduces Risk of Incident Systemic Lupus Erythematosus[J].Arthritis Rheumatol ,2022 02;74(2).</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[6] CHIUVE S E，FUNG T T，RIMM E B，et al．Alternative dietary indices both strongly predict risk of chronic disease[J]．J Nutr，2012，142(6)：1009-1018．</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[7] Fung T T, Meyer H E, Willett W C, et al. Association between Diet Quality Scores and Risk of Hip Fracture in Postmenopausal Women and Men Aged 50 Years and Older[J]. Journal of the Academy of Nutrition and Dietetics, 2018.</span></section><section style="text-align: justify;"><span style="font-size: 16px; line-height: 28px; color: rgb(136, 136, 136);">[8] Scrivo, Rossana &amp; Perricone, Carlo &amp; Altobelli, Alessio &amp; Castellani, Chiara &amp; Tinti, Lorenzo &amp; Conti, Fabrizio &amp; Valesini, Guido. (2019). Dietary Habits Bursting into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies. Nutrients. 11. 1013. 10.3390/nu11051013.</span></section></section></section></section></section></section></section></div></div>

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