<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">单次剂量去甲肾上腺素对腰麻后低血压的预防作用</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-06-29</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创:小麻哥的日常</em></h2></div><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left; font-size: 18px;">【摘要译文】</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">两种初始剂量去甲肾上腺素预防中国产妇剖宫产腰麻后低血压:</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">一项随机、双盲、对照试验</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left; font-size: 18px;">【背景】</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">去甲肾上腺素能有效预防剖宫产腰麻后低血压;然而,尚未确定最佳方案。我们假设,初始剂量的去甲肾上腺素可以提高脊髓性低血压预防的效果,而不仅仅是持续使用去甲肾上腺素。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left; font-size: 18px;">【方法】</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); visibility: visible; box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">在这项双盲对照研究中,120名择期在腰麻下行剖宫产的患者被随机分配接受初始剂量为0.05或0.10μg/kg的去甲肾上腺素,然后以0.05μg·kg<sup>-1</sup>·min<sup>-1</sup>的速率持续输注去甲肾上腺素。主要结局是剖宫产期间腰麻后低血压的发生率。还比较了抢救药物(去氧肾上腺素)的剂量、恶心或呕吐的频率、低血压持续时间、术中高血压的频率、心动过缓的频率和胎儿结局。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left; font-size: 18px;">【结果】</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">115例患者被纳入分析。与初始剂量0.05μg/kg组相比,0.10μg/kg组腰麻后低血压发生率较低(20.7% vs 45.6%;比值比(OR)为0.31;95%可信区间(CI)为0.14-0.71;P=0.004)。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">苯肾上腺素的抢救剂量较低(0[0,0]vs 0[0,80];95%可信区间为0(0-0);P=0.006。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">0.10μg/kg组恶心或呕吐的发生率较低(5.2% vs 17.5%;OR:0.26;95%CI,0.07-0.99;P=0.04)。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">0.10μg/kg组的低血压持续时间短于0.05μg/kg组(0[0,0]vs 0[0,2];95%可信区间为0[0-0];P=0.006)。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">两组之间术中高血压的发生率、心动过缓的频率和胎儿结局具有可比性。</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left; font-size: 18px;">【结论】</span></p><p style="padding: 0px; outline: 0px; max-width: 100%; min-height: 1em; color: rgb(34, 34, 34); font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-align: justify; white-space: normal; background-color: rgb(255, 255, 255); box-sizing: border-box !important; overflow-wrap: break-word !important; line-height: 1.5em; margin-bottom: 28px;"><span style="line-height: 28px; color: rgb(0, 0, 0); font-size: 16px;">在0.05μg·kg<sup>-1</sup>·min<sup>-1</sup>的去甲肾上腺素持续输注量下,0.10μg/kg初始剂量比0.05μg/kg初始剂量更能有效降低腰麻后低血压的发生率。</span></p><!--auditorInfo--><div class="footer"><div class="item"><p class="ysz-ueditor-references-label" >参考文献 <span>共1篇<i></i></span></p><div class="ysz-ueditor-references-content textLine2" lang="en"><p>[1]Lyu W, Wei P, Tang W, Ma X, Zheng Q, Zhou H, Zhou J, Li J. Preventing Spinal Hypotension During Cesarean Birth With Two Initial Boluses of Norepinephrine in Chinese Parturients: A Randomized, Double-Blind, Controlled Trial. Anesth Analg. 2022 Jun 6. doi: 10.1213/ANE.0000000000006110. Epub ahead of print. PMID: 35687059.</p></div></div>

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