<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">美托咪定+布比卡因,联用合理吗?</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-06-27</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创:医学界临床药学频道</em></h2></div><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">联用建议</span><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">布比卡因脊髓阻滞中加入右美托咪定可缩短起效时间,增加感觉和运动阻滞持续时间。</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-title-two" style="font-size: 16px; line-height: 22.5px; font-weight: bold; color: rgb(0, 0, 0); list-style-type: decimal; text-align: left;">相关临床研究结果</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">在一项研究中,接受经尿道前列腺或膀胱肿瘤切除术的患者单独使用高比重布比卡因12 mg(布比卡因0.75%和葡萄糖82.5 mg)或右美托咪定3 μg进行脊髓麻醉。</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">与单独使用布比卡因相比,布比卡因联合右美托咪定组患者的运动阻滞起效时间更短(达到Bromage 3运动阻滞的时间分别为13.2 min和20.7 min)。给予联合用药的患者感觉和运动阻滞的持续时间明显延长。各组之间的心率或平均动脉压没有差异</span><sup><span style="color: rgb(0, 0, 0); font-size: 16px;">[1]</span></sup><span style="color: rgb(0, 0, 0); font-size: 16px;">。</span></p><p><br/></p><!--auditorInfo--><div class="footer"><div class="item"><p class="ysz-ueditor-references-label" >参考文献 <span>共1篇<i></i></span></p><div class="ysz-ueditor-references-content textLine2" lang="en"><p>[1]<span class="appskip" data-appskip="yxjysz" data-appskipobj="{&quot;type&quot;:18,&quot;id&quot;:0,&quot;title&quot;:&quot;&quot;,&quot;url&quot;:&quot;https://xueshu.baidu.com/usercenter/paper/show?paperid=7bb3f9aa77cbfeaabfe475198df7eee4&amp;site=xueshu_se&quot;}">Kanazi GE, Aouad MT, Jabbour-Khoury SI, Al Jazzar MD, Alameddine MM, Al-Yaman R,Bulbul M, Baraka AS. Effect of low dose dexmedetomidine or clonidine on the characteristicsof bupivacaine spinal block. Acta Anaesthesiol Scand (2006) 50, 222–7.</span></p><p><br/></p></div></div>

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