<link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/css/video-js.min.css?v=1"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/base.css?v=5"><link rel="stylesheet" href="https://studioyszimg.yxj.org.cn/article/css/index.css?v=35"><link rel="stylesheet" href="https://ysz-web.yxj.org.cn/live/dist/static/base/index.css?ysz_v=2.0"><script src="https://studioyszimg.yxj.org.cn/js/dsbridge.js?v=13" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/dsBridge/main.js?v=26" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/base/fun.js?ysz_v=3" type="text/javascript"></script><script src="https://ysz-web.yxj.org.cn/live/dist/static/js/nativeToWeb.js?v=1" type="text/javascript"></script><div id="ysz-header" style="margin:0;overflow:hidden;"><h1 style="font-size:24px;line-height:1.8;color:#333333;word-wrap:break-word;">环丙沙星+氯喹,联用合理吗?</h1><h2 style="font-size:16px;color:#999999;word-wrap:break-word;"><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">2022-08-05</em><em style="font-style:normal;margin-right:10px;color:#7f7f7f;display:inline-block;">原创:医学界临床药学频道</em></h2></div><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">联用建议</span><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);"><br/></span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">氯喹可适度降低环丙沙星水平。</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-title-one" style="font-size: 16px; line-height: 28px; font-weight: bold; color: rgb(215, 0, 15); text-align: left;">相关临床研究结果</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">一项在5名健康受试者中进行的研究发现,氯喹可使环丙沙星的最大血浆浓度降低18%,且低于对恶性疟原虫的最低抑菌浓度<sup>[1]</sup>。</span></p><p><br/></p><p style="text-align: justify;"><span class="ysz-ueditor-content" style="font-size: 16px; line-height: 28px; color: rgb(0, 0, 0);">其他文献报道了同样或非常相似的研究<sup>[2]</sup>。这些报告的作者认为,这些报告的作者认为,环丙沙星生物利用度的降低可能对治疗对氯喹耐药的感染有影响。需要更多的研究来确定环丙沙星水平小幅降低的临床相关性。</span></p><!--auditorInfo--><div class="footer"><div class="item"><p class="ysz-ueditor-references-label" >参考文献 <span>共2篇<i></i></span></p><div class="ysz-ueditor-references-content textLine2" lang="en"><p>[1]<span class="appskip" data-appskip="yxjysz" data-appskipobj="{&quot;type&quot;:18,&quot;id&quot;:0,&quot;title&quot;:&quot;&quot;,&quot;url&quot;:&quot;https://xueshu.baidu.com/usercenter/paper/show?paperid=c2cd4f888b1e448b3478f0ef73a58cb1&amp;site=xueshu_se&quot;}">Ilo EC, Orisakwe OE, Ilondu NA, Okwoli N, Brown SA, Elo-Ilo J, Agbasi PU. Effect of chloroquineon the bioavailability of ciprofloxacin in man. J Control Release. (2006) 116, e109–10.</span></p><p style="white-space: normal;">[2]<span class="appskip" data-appskip="yxjysz" data-appskipobj="{&quot;type&quot;:18,&quot;id&quot;:0,&quot;title&quot;:&quot;&quot;,&quot;url&quot;:&quot;https://xueshu.baidu.com/usercenter/paper/show?paperid=9c27368d49bc7f22bf42a2135bb798c2&amp;site=xueshu_se&quot;}">Ilo CE, Ezejiofor NA, Agbakoba N, Brown SA, Maduagwuna CA, Agbasi PU, Orisakwe OE.Effect of chloroquine on the urinary excretion of ciprofloxacin. Am J Ther (2008) 15, 419–22.</span></p></div></div>

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