Introduction. In 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts.

Aim. The aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts.

Method. A comprehensive literature review was performed.

Results. This article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients.

Conclusion. Development of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med **;**:**–**. 

引言。2009年，国际性医学学会（ISSM）召集了一个选定的专家小组，为遭受终生早泄（PE）的患者制定了一套基于证据的指南。该文件审查了定义、病因、对患者和伴侣的影响、评估以及药物、心理和联合治疗。最后，认识到临床研究的不断发展性质，建议随后每4年进行一次指南审查和修订。根据这一建议，ISSM于2013年4月组织了第二个多学科专家小组，在印度班加罗尔举行了为期2天的会议。本手稿更新了以前的指南和关于专家小组建议的报告。

Aim。本研究的目的是为家庭医生和性医学专家制定明确措辞、实用、基于证据的PE诊断和治疗建议。

方法。进行了全面的文献综述。

结果。本文包含第二个ISSM PE指南委员会的报告。它提供了PE的新的统一定义，并更新了以往的治疗建议。描述了简短的评估程序，并审查了经验证的诊断和治疗问卷。最后，提出了最佳实践治疗建议，以指导熟悉和不熟悉PE的临床医生促进患者的治疗。

结论。指南的制定是一个不断审查数据并结合最佳新研究的进化过程。我们期望正在进行的研究将导致对这种性功能障碍的病理生理学以及新的有效和安全的治疗有更完整的了解。我们再次建议ISSM在4年内对这些指南进行重新评价和更新。Althof SE、McMahon CG、Waldinger MD、Serefoglu EC、Shindel AW、Adaikan PG、Becher E、Dean J、Giuliano F、Hellstrom WJG、Giraldi A、Glina S、Incrocci L、Jannini E、McCabe M、Parish S、Rowland D、Segraves RT、Sharlip I和Torres LO。更新国际性医学学会早泄（PE）诊断和治疗指南。性别医学**；**：**–**.