Background: Actinic keratoses (AK) are rough scaly patches that arise on chronically ultraviolet-exposed skin and can progress to keratinocyte carcinoma. Treatment options for AK include topical medications, photodynamic therapy, cryosurgery, and laser ablation.

Objective: This executive summary provides a synopsis of the 18 evidence-based recommendations for the treatment of AK detailed in the Guidelines of Care for the Management of Actinic Keratosis.

Methods: A multidisciplinary workgroup conducted a systematic review to address 5 clinical questions on the management of AKs and applied the Grading of Recommendations Assessment, Development and Evaluation approach for assessing the certainty of the evidence and formulating and grading clinical recommendations. Graded recommendations were voted on to achieve consensus.

Results: Analysis of the evidence resulted in 18 recommendations, suggesting there are several effective treatments available for AK.

Limitations: The analysis informing the recommendations was based on the best available evidence at the time it was conducted. The results of future studies may necessitate a revision of current recommendations.

Conclusions: Strong recommendations are presented for using ultraviolet protection, topical imiquimod, topical 5-fluorouracil, and cryosurgery. Conditional recommendations are presented for the use of photodynamic therapy and diclofenac for the treatment of AK, both individually and as part of combination therapy regimens. 

背景：光化性角化病 (AK) 是发生于长期紫外线暴露皮肤上的粗糙鳞屑性斑片，可进展为角质形成细胞癌。AK的治疗选择包括局部药物、光动力疗法、冷冻手术和激光消融。

目的：本执行摘要提供了光化性角化病治疗指南中详述的18项 AK 治疗循证建议的概要。

方法：多学科工作组进行了一项系统性综述，以解决关于 AK 治疗的5个临床问题，并应用建议分级评估、开发和评价方法来评估证据的确定性以及制定和分级临床建议。对分级建议进行了表决，以达成共识。

结果：证据分析得出了18条建议，表明 AK 有几种有效的治疗方法。

局限性：告知建议的分析是基于进行时的最佳可用证据。未来研究的结果可能需要修订当前的建议。

结论：强烈建议使用紫外线保护、外用咪喹莫特、外用5-氟尿嘧啶和冷冻手术。提供了使用光动力疗法和双氯芬酸治疗 AK 的条件性建议，包括单独治疗和作为联合治疗方案的一部分。