Background: New evidence has emerged since the 2014 guidelines that further informs the management of atopic dermatitis (AD) with topical therapies. These guidelines update the 2014 recommendations for management of AD with topical therapies.

Objective: To provide evidence-based recommendations related to management of AD in adults using topical treatments.

Methods: A multidisciplinary workgroup conducted a systematic review and applied the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach for assessing the certainty of evidence and formulating and grading recommendations.

Results: The workgroup developed 12 recommendations on the management of AD in adults with topical therapies, including nonprescription agents and prescription topical corticosteroids (TCS), calcineurin inhibitors (TCIs), Janus kinase (JAK) inhibitors, phosphodiesterase-4 inhibitors (PDE-4), antimicrobials, and antihistamines.

Conclusions: Strong recommendations are made for the use of moisturizers, TCIs, TCS, and topical PDE-4 and JAK inhibitors. Conditional recommendations are made for the use of bathing and wet wrap therapy and against the use of topical antimicrobials, antiseptics, and antihistamines.

背景：自2014年指南以来出现了新的证据，进一步告知特应性皮炎 (AD) 的局部治疗管理。这些指南更新了2014年关于外用治疗AD管理的建议。

目的：提供与外用治疗成人AD管理相关的循证建议。

方法：多学科工作组进行了系统综述，并应用GRADE（建议、评估、开发和评价分级）方法评估证据的确定性以及制定和分级建议。

结果：工作组制定了12项关于外用治疗成人AD管理的建议，包括非处方药和处方外用皮质类固醇(TCS)、钙调磷酸酶抑制剂(TCI)、Janus激酶 (JAK)抑制剂、磷酸二酯酶-4抑制剂(PDE-4)、抗菌剂和抗组胺药。

结论：强烈建议使用保湿剂、TCI、TCS和外用 PDE-4 和JAK 抑制剂。对使用沐浴和湿包裹治疗以及禁止使用局部抗菌剂、防腐剂和抗组胺药提出了条件性建议。