Background: Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older.

Objective: The objective of this study was to provide evidence-based recommendations for the management of acne.

Methods: A work group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations.

Results: This guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.

Limitations: Analysis is based on the best available evidence at the time of the systematic review.

Conclusions: These guidelines provide evidence-based recommendations for the management of acne vulgaris.

背景：寻常痤疮通常影响成人、青少年和9岁或以上的青少年前期。

目的：本研究的目的是为痤疮的管理提供循证建议。

方法：一个工作组进行了系统回顾，并应用推荐、评估、开发和评价分级方法来评估证据的确定性以及制定和分级

建议。

结果：本指南提供了18条基于证据的建议和5条良好实践声明。对过氧苯甲酰、外用维 A 酸、外用抗生素和口服多西环素提出了强烈建议。口服异维 A 酸强烈建议用于严重痤疮、引起心理社会负担或瘢痕、标准口服或外用治疗失败的痤疮。对于外用克拉索替林、水杨酸和壬二酸，以及口服米诺环素、沙雷西林、复方口服避孕药和螺内酯，有条件的推荐。将具有多种作用机制的外用治疗组合、限制全身性抗生素使用、全身性抗生素与外用治疗组合以及对较大痤疮皮损增加皮损内皮质类固醇注射作为良好实践声明。

局限性：分析是基于系统性综述时的最佳可用证据。