Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, predominantly drug-induced, acute life-threatening diseases of skin and mucosae. SJS and TEN are nowadays considered as variants of one disease entity with varying degrees of severity called epidermal necrolysis (EN). EN is associated with high morbidity and mortality and constitutes a major disease burden for affected patients. The guideline "Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis)" was developed under systematic consideration of existing scientific literature and in a formal consensus process according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF) to establish an evidence-based framework to support clinical decision-making. The interdisciplinary guideline commission consisted of representatives from various specialist societies and of patient representatives. The guideline is aimed at specialists in the fields of dermatology, ophthalmology, plastic surgery, intensive care, and pediatrics in hospitals and offices, as well as other medical specialties involved in the diagnosis and treatment of EN. The guideline is also aimed at patients, their relatives, insurance funds, and policymakers. The second part is concerned with the topics of supportive therapy in the acute phase of EN and outpatient follow-up treatment.

史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症（SJS/TEN）是罕见的，主要是药物引起的，急性危及生命的皮肤和粘膜疾病。SJS和TEN现在被认为是一种疾病实体的变体，具有不同程度的严重程度，称为表皮坏死松解（EN）。EN与高发病率和死亡率相关，并构成受影响患者的主要疾病负担。指南“表皮坏死松解（Stevens-Johnson综合征和中毒性表皮坏死松解）的诊断和治疗”是根据德国科学医学学会协会（AWMF）发布的规定，在系统考虑现有科学文献和正式共识过程的基础上制定的，旨在建立一个以证据为基础的框架，以支持临床决策。跨学科指南委员会由来自不同专科学会的代表和患者代表组成。该指南的对象是医院和办公室的皮肤科、眼科、整形外科、重症监护和儿科领域的专家，以及参与鼻炎诊断和治疗的其他医学专业。该指南还针对患者、家属、保险基金和政策制定者。第二部分是关于支持治疗在急性期EN和门诊随访治疗的主题。