The Japanese Society of Mood Disorders (JSMD) published treatment guidelines of bipolar disorder in 2011. The present guidelines incorporating new findings were developed to comply to the guidelines of the National Academy of Medicine (NAM) by utilizing systematic reviews and meta-analysis and taking patient and family opinions as well as insights from multiple professional fields into account. They support combination therapy using mood stabilizers and second-generation antipsychotics in many aspects. They also have limitations, including the grouping of mood stabilizers and second-generation antipsychotics when meta-analysis was performed despite their distinct properties, due to the scarcity of drug-specific evidence. Despite the limitations, these guidelines provide clinical decision support for psychiatrists in Japan.

日本情绪障碍协会（JSMD）于2011年发布了双相情感障碍的治疗指南。本指南纳入了新发现，是为了遵守美国国家医学院（NAM）的指导方针而制定的，通过利用系统评价和荟萃分析，并考虑到患者和家属的意见以及多个专业领域的见解。他们在许多方面支持使用情绪稳定剂和第二代抗精神病药物的联合治疗。它们也有局限性，包括在进行荟萃分析时将情绪稳定剂和第二代抗精神病药物分组，尽管它们具有不同的特性，但由于缺乏药物特异性证据。尽管存在局限性，但这些指南为日本的精神科医生提供了临床决策支持。