This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.

该指南为使用多西环素暴露后预防（DoxyPEP）预防梅毒提供了循证建议。DoxyPEP应作为性传播感染（STI）综合预防策略的组成部分，需与以下措施联合实施：安全套使用、适宜的HIV预防干预、疫苗接种、STI检测与治疗管理，以及基于风险评估的针对性健康指导及必要的心理干预。