Background Peripartum depression (PPD) is a prevalent mental health disorder in the peripartum period. However, a recent systematic review of clinical guidelines relating to PPD has revealed a significant inconsistency in recommendations. Aims This study aimed to collect up-to-date evidence on the effectiveness of interventions and provide recommendations for prevention, screening and treating PPD. Method A series of umbrella reviews on the effectiveness of PPD prevention, screening and treatment interventions was conducted. A search was performed in five databases from 2010 until 2023. The guidelines were developed according to the GRADE framework and AGREE II Checklist recommendations. Public stakeholder review was included. Results One hundred and forty-five systematic reviews were included in the final analysis and used to form the guidelines. Forty-four recommendations were developed, including recommendations for prevention, screening and treatment. Psychological and psychosocial interventions are strongly recommended for preventing PPD in women with no symptoms and women at risk. Screening programmes for depression are strongly recommended during pregnancy and postpartum. Cognitive–behavioural therapy is strongly recommended for PPD treatment for mild to severe depression. Antidepressant medication is strongly recommended for treating severe depression in pregnancy. Electroconvulsive therapy is strongly recommended for therapy-resistant and life-threatening severe depression during pregnancy. Other recommendations are offered to healthcare professionals, stakeholders and researchers in managing PPD in different contexts. Conclusion Treatment recommendations should be implemented after carefully considering clinical severity, previous history, risk–benefit for mother and foetus/infant and women’s values and preferences. Implementation of evidence-based clinical practice guidelines within country-specific contexts should be facilitated.

背景：围产期抑郁症（PPD）是围产期一种普遍的心理健康障碍。然而，近期一项关于PPD临床指南的系统性评价揭示了推荐意见存在显著不一致。目的 本研究旨在收集关于干预措施有效性的最新证据，并为PPD的预防、筛查和治疗提供推荐意见。

方法：针对PPD预防、筛查和治疗干预措施的有效性进行了一系列伞状评价（umbrella reviews）。研究检索了五个数据库从2010年至2023年的文献。指南的制定依据GRADE框架和AGREE II清单推荐意见进行，并纳入了公众利益相关者审查。

结果：最终分析纳入了145篇系统性评价，并用于形成指南。共制定了44条推荐意见，涵盖预防、筛查和治疗。对于无症状女性和高危女性，强烈推荐使用心理和社会心理干预措施预防PPD。强烈推荐在孕期和产后实施抑郁症筛查项目。对于轻至重度PPD的治疗，强烈推荐使用认知行为疗法。强烈推荐使用抗抑郁药物治疗妊娠期重度抑郁症。对于妊娠期难治性且危及生命的重度抑郁症，强烈推荐使用电休克治疗。还为医疗保健专业人员、利益相关者和研究人员提供了在不同情境下管理PPD的其他建议。

结论：实施治疗推荐意见时，应仔细考虑临床严重程度、既往病史、对母亲和胎儿/婴儿的风险-获益以及女性的价值观和偏好。应促进在特定国家背景下实施循证临床实践指南。